The more important question here is how you set yourself up with so many internal drives. There is no valid reason to have that much internal hard drive space for file storage in my opinion.
3 of the drives are internal, one is an external usb drive (200 Gb/ storage and saved stuff from old PC). Inside drives, #1 (120 Gb) Used for OS and most Apps. #2 (300 Gb sata) Used for storage and due to running out of room on the other drives, some games and apps but I keep that to a minimum, usualy just older games I like to play now and then like GTA vc. #3 74 Gb WD Raptor, Games, nothing more, nothing less.
Reason? I always recall reading that running ones OS and apps on seperate drives was of great advantage in the fact that the os isnt constantly querrying a single drive / by using a seperate drive for apps and games it prevents bottlenecking traffic of both OS and app traffic.
***Update***
Got bored after 16 hours and decided to chance some Xfire / Teamspeak / COD UO and it actually ran as good as it had prior to my noticing it was time for a defrag in the first place with defrag running in the background (There was an occasional studder to it, but it was short lived and alot rarer than one might expect it to be / 3-4 minute intervals). No doubt added some time to the defrag process but it's nice to see that they've eliminated the need to set up absolute idle time for the PC to take care of this lil' nessisary evil.
***Update x2*** 23.5 hours later, I'm good to go. Think I'll go grab Dr. J's suggestion for the next time I do this (In 2 weeks or so).
***Update x3*** Grabbed iobit and spun the wheels. Nice that it seems much more familiar (Being able to watch the drive defrag like a game of Tetris on auto-pilot) and it's not resource intensive meaning I can defrag my external drive and my game drive while I watch a movie on the storage drive, or storage drive and play a game and do the os / app drive while I sleep. Thanks for the heads up Dr J, +'s 2 ya